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Similar characteristics of nontuberculous mycobacterial pulmonary disease in men and women
Selasa, 23 Apr 2019 14:54:35

M.R. HoltS.H. KasperbauerT.L. KoelschC.L. Daley

European Respiratory Journal 2019; DOI: 10.1183/13993003.00252-2019

Extract

The characteristics of nontuberculous mycobacterial pulmonary disease (NTM-PD) in individuals without clinically apparent predisposing factors have been described in female-predominant cohorts. Phenotypic characteristics are advanced age, tall stature, slender body habitus, right middle lobe (RML)- and/or lingula-predominant nodular bronchiectasis and increased frequencies of scoliosis, pectus excavatum (PEX) and mitral valve prolapse [1–3]. Increased rates of cystic fibrosis transmembrane conductance regulator (CFTR), immune, ciliary and connective tissue gene mutations and abnormal alpha-1-antitrypsin (AAT) phenotypes have also been reported [4, 5]. The phenotypic archetype of NTM-PD in men is upper lobe cavitation in a middle-aged smoker. We hypothesised that the characteristics of male patients without pre-existing structural lung disease and immunocompromise resemble those of female patients.

Footnotes

This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.

Conflict of interest: Dr. Holt reports being an investigator in Insmed studies, outside the submitted work.

Conflict of interest: Dr. Kasperbauer reports personal fees from Insmed, outside the submitted work.

Conflict of interest: Dr. Koelsch has nothing to disclose.

Conflict of interest: Dr. Daley reports grants and personal fees from Insmed, outside the submitted work.