M.R. Holt, S.H. Kasperbauer, T.L. Koelsch, C.L. Daley
European Respiratory Journal 2019; DOI: 10.1183/13993003.00252-2019
The characteristics of nontuberculous mycobacterial pulmonary disease (NTM-PD) in individuals without clinically apparent predisposing factors have been described in female-predominant cohorts. Phenotypic characteristics are advanced age, tall stature, slender body habitus, right middle lobe (RML)- and/or lingula-predominant nodular bronchiectasis and increased frequencies of scoliosis, pectus excavatum (PEX) and mitral valve prolapse [1–3]. Increased rates of cystic fibrosis transmembrane conductance regulator (CFTR), immune, ciliary and connective tissue gene mutations and abnormal alpha-1-antitrypsin (AAT) phenotypes have also been reported [4, 5]. The phenotypic archetype of NTM-PD in men is upper lobe cavitation in a middle-aged smoker. We hypothesised that the characteristics of male patients without pre-existing structural lung disease and immunocompromise resemble those of female patients.
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Conflict of interest: Dr. Holt reports being an investigator in Insmed studies, outside the submitted work.
Conflict of interest: Dr. Kasperbauer reports personal fees from Insmed, outside the submitted work.
Conflict of interest: Dr. Koelsch has nothing to disclose.
Conflict of interest: Dr. Daley reports grants and personal fees from Insmed, outside the submitted work.