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Tuberculosis following Renal Transplantation in England, Wales and Northern Ireland
Senin, 01 Jul 2019 10:17:26

Rishi K. GuptaGabriel RosenbergJaran EriksenMarc LipmanCharlotte JacksonAnjana RoyDominik ZennerColette SmithMark HarberColin CampbellIbrahim Abubakar

European Respiratory Journal 2019; DOI: 10.1183/13993003.02245-2018

Tuberculosis following Renal Transplantation in England, Wales and Northern Ireland : A National Registry-based Cohort Study


Extract

Increased tuberculosis (TB) disease risk has consistently been observed among solid organ transplant recipients [1, 2]. This may result from post-transplant immunosuppressive therapy, although underlying disease processes leading to transplant (including chronic kidney disease) are also associated with increased risk [3]. TB among transplant recipients is associated with increased risk of drug toxicity, drug-drug interactions, graft failure, and mortality [4] and can lead to transmission to other vulnerable hospitalised patients. Consequently, global guidelines recommend systematic screening patients undergoing solid organ transplant for latent tuberculosis infection (LTBI) [3].

Footnotes

This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.

Conflict of interest: Dr. Gupta has nothing to disclose.

Conflict of interest: Dr. Rosenberg has nothing to disclose.

Conflict of interest: Dr. Eriksen has nothing to disclose.

Conflict of interest: Dr. Lipman has nothing to disclose.

Conflict of interest: Dr. Jackson has nothing to disclose.

Conflict of interest: Dr. Roy has nothing to disclose.

Conflict of interest: Dr. Zenner has nothing to disclose.

Conflict of interest: Dr. Smith reports personal fees from Gilead Sciences, personal fees from ViiV Healthcare, outside the submitted work.

Conflict of interest: Dr. Harber has nothing to disclose.

Conflict of interest: Dr. Campbell has nothing to disclose.

Conflict of interest: Dr. Abubakar has nothing to disclose.