Berita Kesehatan
New radiological diagnostic criteria – impact on idiopathic pulmonary fibrosis diagnosis
Jumat, 30 Ags 2019 08:10:00

Manuela Funke-ChambourSabina A. GulerThomas GeiserAndreas ChristeJohannes HeverhagenAlexander PöllingerAdrian HuberLukas Ebner

European Respiratory Journal 2019; DOI: 10.1183/13993003.00905-2019


The ATS/ERS/JRS/ALAT recently released a new clinical practice guideline (ATS/ERS/JRS/ALAT2018) for idiopathic pulmonary fibrosis (IPF) with simultaneously proposed diagnostic criteria by the Fleischner Society. [1, 2] Both diagnostic algorithms agree on most diagnostic steps, with divergent recommendations on the position of surgical lung biopsy (SLB): ATS/ERS/JRS/ALAT2018 recommends SLB in most patients with probable usual interstitial pneumonia (UIP) pattern on high-resolution computed tomography (HRCT) (conditional recommendation), whereas the Fleischner society proposes to forgo SLB in patients with definite or probable UIP HRCT pattern, presenting in the right clinical context. [3, 4] We aimed to quantify the impact of the previous (ATS/ERS/JRS/ALAT2011) [5] and the two new diagnostic approaches [1, 2] on real-life clinical practice, with assessment of radiological inter-rater agreement, diagnostic test characteristics, and prognostic validity of the diverging radiological diagnoses for a multidisciplinary IPF diagnosis in our cohort.


This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.

Conflict of interest: Dr. Funke-Chambour reports grants from Roche, grants from Boehringer Ingelheim, grants from Intermune, during the conduct of the study.

Conflict of interest: Dr. Guler has nothing to disclose.

Conflict of interest: Dr. Geiser has nothing to disclose.

Conflict of interest: Dr. Christe has nothing to disclose.

Conflict of interest: Dr. Heverhagen has nothing to disclose.

Conflict of interest: Alexander Pollinger

Conflict of interest: Dr. Huber has nothing to disclose.

Conflict of interest: Dr. Ebner has nothing to disclose.

Conflict of interest: Dr. Poellinger has nothing to disclose.

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