Berita Kesehatan
Fatty Airways: Implications for Obstructive Disease
Kamis, 24 Okt 2019 16:54:39

John G. Elliot,Graham M. Donovan, Kimberley C.W. Wang, Francis H.Y. Green, Alan L. James, Peter B. Noble

European Respiratory Journal 2019; DOI: 10.1183/13993003.00857-2019

Abstract

Epidemiological studies report that overweight or obese asthmatic subjects have more severe disease than those of a healthy weight. We postulated accumulation of adipose tissue within the airway wall may occur in overweight patients and contribute to airway pathology. Our aim was to determine the relationship between adipose tissue within the airway wall and body mass index (BMI) in individuals with and without asthma.

Transverse airway sections were sampled in a stratified manner from post-mortem lungs of control subjects (n=15) and cases of nonfatal (NFA, n=21) and fatal (FA, n=16) asthma. The relationship between airway adipose tissue, remodelling and inflammation was also assessed. The areas of the airway wall and adipose tissue were estimated by point count and expressed as area per mm of basement membrane perimeter (Pbm). The number of eosinophils and neutrophils were expressed as area densities.

BMI ranged from 15 to 45 (kg·m−2) and was greater in NFA (p<0.05). Adipose tissue was identified in the outer wall of large airways (Pbm>6 mm), but was rarely seen in small airways (Pbm<6 mm). Adipose tissue area correlated positively with BMI and airway wall thickness in all groups. Densities of neutrophils correlated with adipose tissue area in control subjects (Pbm>6 mm, p=0.04) and both neutrophils and eosinophils in FA (Pbm>12 mm, p<0.01).

These data show that adipose tissue is present within the airway wall and is related to BMI, wall thickness and the number of inflammatory cells. The accumulation of airway adipose tissue in overweight individuals may therefore contribute to airway pathophysiology.

Footnotes

This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.

Conflict of interest: Dr. Elliot has nothing to disclose.

Conflict of interest: Dr. Donovan has nothing to disclose.

Conflict of interest: Dr. Wang has nothing to disclose.

Conflict of interest: Dr. Green has nothing to disclose.

Conflict of interest: Dr. James has nothing to disclose.

Conflict of interest: Dr. Noble has nothing to disclose.

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