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COPD frequent exacerbators: time for the recycle bin?
Selasa, 16 Feb 2021 09:34:52

Robert A. Stockley

European Respiratory Journal 2021 57: 2003758; DOI: 10.1183/13993003.03758-2020


COPD is a highly prevalent chronic disease with increased mortality and morbidity. The chronic symptoms result in impaired quality of life interspersed with episodes of acute worsening (exacerbations), which increase patient stress, and the likelihood of hospital admissions and death. These episodes are not only dangerous but also worsen background quality of life, increase the general healthcare burden and lead to disease progression [1, 2]. Therefore, they represent a key target in patient management and have become a primary clinical outcome measure in pharmaceutical drug registration.

The definition of frequent exacerbators has changed with time. The use of previous history to identify frequent exacerbators is far from robust and has implications for the instigation of therapy based on the current GOLD algorithm.


  • Conflict of interest: R.A. Stockley has nothing to disclose.

  • Received October 7, 2020.
  • Accepted October 12, 2020.
  • Copyright ©ERS 2021