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Repeatability of impulse oscillometry in patients with severe asthma

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Rabu, 13 Okt 2021 15:08:58

Rory Chan, Rasads Misirovs, Brian Lipworth

European Respiratory Journal 2021; DOI: 10.1183/13993003.01679-2021

Extract

Impulse oscillometry (IOS) involves an effort independent tidal breathing manoeuvre to determine the presence or absence of small airways dysfunction (SAD), defined as raised peripheral airway resistance (difference in resistance between 5 and 20â€…Hz (R5-R20)) and/or raised peripheral airway reactance (area under the reactance curve (AX)) [1]. IOS has clear advantages over spirometry especially in patients where accurate forced volumetric measurements may be difficult or impossible to achieve, and has proven its utility in asthma and COPD although work is still required to determine normal reference ranges and the minimal clinically important difference (MCID) for changes in measurements [2].

Footnotes

This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.

Conflict of interest: Dr. Chan has no relevant conflicts of interest.

Conflict of interest: Dr. Misirovs has no relevant conflicts of interest.

Conflict of interest: Dr. Lipworth reports non-financial support (equipment) from GSK; grants, personal fees (consulting, talks and advisory board), other support (attending ATS and ERS) and from AstraZeneca, grants, personal fees (consulting, talks, advisory board), other support (attending ERS) from Teva, personal fees (consulting) from Sanofi, personal fees (consulting, talks and advisory board) from Circassia in relation to the submitted work; personal fees (consulting) from Lupin, personal fees (consulting) from Glenmark, personal fees (consulting) from Vectura, personal fees (consulting) from Dr Reddy, personal fees (consulting) from Sandoz; grants, personal fees (consulting, talks, advisory board), other support (attending BTS) from Boehringer Ingelheim, grants and personal fees (advisory board and talks) from Mylan outside of the submitted work; and the son of BJL is presently an employee of AstraZeneca.