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Cough Hypersensitivity Syndrome: Clinical Measurement is the Key to Progress
Rabu, 07 Nov 2018 15:05:44

The recent European Respiratory Society (ERS) Task Force Report on chronic cough should be commended for drawing attention to a neglected area of respiratory medicine and discussing controversies surrounding the approach to this common clinical problem. Cough hypersensitivity syndrome is proposed as a new shorthand to refer to patient-reported excessive coughing that otherwise evades clinical explanation. As discussed in the report, cough hypersensitivity syndrome may or may not be associated with other causes of chronic cough, and its peripheral and central mechanisms are only partly understood .

The comparison of cough hypersensitivity syndrome with chronic obstructive pulmonary disease (COPD) as an umbrella term is useful in recognising the existence of distinct cough phenotypes. These might be described according to underlying pathology, for example excessive coughing associated with: airway inflammation (asthma or bronchitis); infection (respiratory tract infection, pneumonia or tuberculosis); anatomic airway distortion (lung cancer or fibrosis); mechanical irritation (acid reflux or post-nasal drip); and cough in the absence of known pathology. The analogy ends there. While COPD has clear diagnostic criteria involving objective measurement this is not the case for cough hypersensitivity syndrome.

Cough, as a clinical problem, and as currently discussed in guidelines and consensus statements, is a symptom. This is distinct from coughing reported by an observer, cough measured objectively by acoustic monitoring, or cough induced experimentally by an inhaled irritant. Indeed, not only does patient-reported chronic cough correlate poorly with cough reflex sensitivity to inhaled capsaicin or citric acid (as acknowledged by the task force), it also correlates only moderately with objectively measured cough frequency. Patient-reported cough improves with placebo (as in randomised controlled trials of proton pump inhibitors) and behavioural training. It can also improve spontaneously, despite a long duration and failed trials of treatment. Explanation of these facts is currently limited.

Basic questions about cough remain unanswered. There are few descriptions of how much coughing is “normal” (and how much should be regarded as pathological). Improved understanding of cough will only come about through measurement and objective description of clinical and physiological phenomena. The objective measurement of cough frequency is of prime importance. This should be carried out in a large range of patients and respiratory conditions, as well as in healthy controls, and repeated over time, during the natural history of disease and in response to treatments. This will be made possible by agreement on how to count coughs, and the further development and increased availability of automated cough monitoring. Objective cough counts should then be related to clinical and genetic variables, measures of respiratory tract inflammation (possibly including profiles of exhaled volatile organic compounds (VOCs) and neuronal and central factors, and compared with subjective concerns and symptoms. In this way cough phenotypes will be much more rigidly defined in terms of symptoms, coughing behaviour and mechanisms.


Clinical tools for measurement of cough

Variable Tool Adaptable to routine practice? References
Cough symptoms
 Subjective cough severity Visual analogue scale Yes [6]
 Cough-related quality of life Leicester cough questionnaire, cough-specific quality of life  questionnaire Yes [6]
Objective description of coughing
 Temporal cough patterns# Ambulatory cough monitoring Yes [6, 7]
 Force/intensity of coughs Airflow measurements, electromyography, oesophageal  pressure monitoring Possibly [7]
 Sensitivity to inhaled irritants Inhalational cough challenge Possibly [6]
Cough mechanism
 Airway inflammation BAL sample analysis, induced sputum cell counts, exhaled nitric  oxide fraction, exhaled volatile organic compounds Yes [1, 9]
 Neuronal mechanisms Animal models, human surgical and autopsy specimens No [6]
 Central pathways Functional magnetic resonance imaging Possibly [10]
 Genetic predisposition Genotyping for single nucleotide polymorphisms of potential  genes including TRPV1 Possibly [8, 10]
  • BAL: bronchoalveolar lavage. #: daily cough frequency, diurnal cough pattern and degree of clustering of coughs into bouts.

Many of these measurements can be employed in routine clinical practice, at least in specialist clinics, although the available tools are currently in varying stages of development. For example, automated or semi-automated cough monitors are still being refined and are currently only used in research groups. An ambulatory method of measuring cough intensity is required. Available standard inhalation cough challenge tests do not currently differentiate health from disease. Analysis of exhaled VOCs is still in its infancy, the cost of functional magnetic resonance imaging and genotyping may be a limiting factor, and the genetic basis of variations in cough perception and frequency has yet to be elucidated.

A previous ERS task force addressed the assessment of cough 8 years ago. Unfortunately, there have been few advances in the tools available to measure cough since then. This is a priority for cough research. Measurement will not only allow cough hypersensitivity syndrome and other phenomena to be characterised with greater precision, it is the key to progress in this field.