KLINIK RESPIRASI. Klinik Dokter THT di Malang, Klinik Dokter Paru di Malang, Klinik Jantung di Malang, Klinik Dokter Paru di Surabaya, Klinik Dokter Penyakit Dalam di Malang, Klinik Dokter Gigi di Malang, Klinik Dokter Gigi di Serpong

Berita Kesehatan

Altered pulmonary capillary blood volume in childhood sickle cell disease

Image :

Rabu, 21 Jun 2023 13:32:13

PlamenÂ Bokov,Â PriscillaÂ Boizeau,Â JadeÂ Pautrat,Â FlorenceÂ Missud,Â AissatouÂ Ba,Â ZinÃ©dineÂ Haouari,Â AndrÃ©Â Denjean,Â ChristopheÂ Delclaux,Â MalikaÂ Benkerrou

European Respiratory JournalÂ 2020Â 56:Â 2000379;Â DOI:Â 10.1183/13993003.00379-2020

Extract

It has consistently been shown that patients with sickle cell disease (SCD) exhibit a compensatory increase in pulmonary capillary blood volume (PCBV), at least in a specific subgroup of patients [1]. This increase in PCBV could be related to the anaemia-induced increase in cardiac output [2]. ChaudryÂ et al.Â [3] showed that SCD patients failed to recruit and dilate their pulmonary capillary bed to the same extent as control subjects for a given rise in effective pulmonary blood flow. One may therefore hypothesise that PCBV is already maximally recruited at rest; however, this has yet to be confirmed. Furthermore, it is not clear whether this potential defective pulmonary vascular recruitment is related to SCD history.

Children with sickle cell disease have a pulmonary capillary blood volume that is already dilated at rest and that may initiate a restrictive defectÂ https://bit.ly/2MRaqkc

Acknowledgements

P. Bokov and C. Delclaux thank Nicole Beydon for initiating the subject of the present study.

Footnotes

Conflict of interest: P. Boizeau has nothing to disclose.
Conflict of interest: J. Pautrat has nothing to disclose.
Conflict of interest: F. Missud has nothing to disclose.
Conflict of interest: A. Ba has nothing to disclose.
Conflict of interest: Z. Haouari has nothing to disclose.
Conflict of interest: A. Denjean has nothing to disclose.
Conflict of interest: C. Delclaux has nothing to disclose.
Conflict of interest: M. Benkerrou has nothing to disclose.
Conflict of interest: P. Bokov has nothing to disclose.
Support statement: This study was supported by the Assistance Publique â€“ HÃ´pitaux de Paris. Funding information for this article has been deposited with theÂ Crossref Funder Registry.