Plamen Bokov, Priscilla Boizeau, Jade Pautrat, Florence Missud, Aissatou Ba, Zinédine Haouari, André Denjean, Christophe Delclaux, Malika Benkerrou
European Respiratory Journal 2020 56: 2000379; DOI: 10.1183/13993003.00379-2020
It has consistently been shown that patients with sickle cell disease (SCD) exhibit a compensatory increase in pulmonary capillary blood volume (PCBV), at least in a specific subgroup of patients [1]. This increase in PCBV could be related to the anaemia-induced increase in cardiac output [2]. Chaudry et al. [3] showed that SCD patients failed to recruit and dilate their pulmonary capillary bed to the same extent as control subjects for a given rise in effective pulmonary blood flow. One may therefore hypothesise that PCBV is already maximally recruited at rest; however, this has yet to be confirmed. Furthermore, it is not clear whether this potential defective pulmonary vascular recruitment is related to SCD history.
Children with sickle cell disease have a pulmonary capillary blood volume that is already dilated at rest and that may initiate a restrictive defect https://bit.ly/2MRaqkc
P. Bokov and C. Delclaux thank Nicole Beydon for initiating the subject of the present study.
Conflict of interest: P. Boizeau has nothing to disclose.
Conflict of interest: J. Pautrat has nothing to disclose.
Conflict of interest: F. Missud has nothing to disclose.
Conflict of interest: A. Ba has nothing to disclose.
Conflict of interest: Z. Haouari has nothing to disclose.
Conflict of interest: A. Denjean has nothing to disclose.
Conflict of interest: C. Delclaux has nothing to disclose.
Conflict of interest: M. Benkerrou has nothing to disclose.
Conflict of interest: P. Bokov has nothing to disclose.
Support statement: This study was supported by the Assistance Publique – Hôpitaux de Paris. Funding information for this article has been deposited with the Crossref Funder Registry.