Corrine R. Kliment, Reinoud Gosens
European Respiratory Journal 2022 60: 2201356; DOI: 10.1183/13993003.01356-2022
Extract
Chronic inflammation of the airways and lung tissue is an important feature of COPD. In recent years, a role for mast cells has emerged in numerous diseases, including COPD [1–4]. Mast cells are long-lived tissue-resident immune cells that secrete proteases and chymases (such as CMA1), interact with antigen-presenting cells and mediate immune responses [5]. These granule-filled cells were first described by Ehrlich [6] in 1878. The role of mast cells in lung disease has been shown in asthma [7], but remains relatively unexplored in COPD. In patients with COPD, there are changes in the density and localisation of tissue-resident mast cells [1, 2, 4, 8].
Mast cells are emerging as an important cell type in the chronic inflammation present in COPD and are poised to be the focus of future therapeutic approaches. https://bit.ly/3yotNbW
Footnotes
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Conflict of interest: C.R. Kliment declares no competing interests.
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Conflict of interest: R. Gosens declares grant funding to their institution from Aquilo BV, Boehringer Ingelheim and Sanofi-Genzyme, in the 36 months prior to manuscript submission.
- Received July 7, 2022.
- Accepted July 7, 2022.
- Copyright ©The authors 2022. For reproduction rights and permissions contact
